Endometrial Adenocarcinoma in PCOS

Abstract

Endometrial cancer refers to several types of malignancy which arise from the endometrium or lining of the uterus. Endometrial carcinoma usually occurs in women above 40 years of age and presents as abnormal vaginal bleeding. Even though literature says, endometrial carcinoma rare in young females both of our females in their prime age succumbed to malignancy. The incidence varies widely throughout the world. It is the most common invasive tumor of the female genital tract in the U.S. and is decreasing in frequency in women in their 50s in whom it is related to unopposed estrogen stimulation. In developing countries, the incidence is four to five times less. Worldwide, it is the fifth commonest cancer in women. Clinical behavior of endometrial adenocarcinoma depends on the histologic type, the grade (degree of differentiation) and the stage (extent of spread). Endometrioid carcinoma has a better prognosis than the other histologic types, which tend to occur at a higher stage Patients with endometrial cancer who have localized disease are usually curable by hysterectomy and bilateral salpingo-oophorectomy. Best results are obtained with either of two standard treatments: hysterectomy or hysterectomy and adjuvant radiation therapy