Advances in the Management of Type 2 Diabetes Mellitus

Abstract

Diabetes mellitus is a chronic metabolic disorder of the endocrine system, characterized by a complex and varied pathophysiology. Worldwide, there is a dramatic increase in the number of patients with type 2 diabetes, and hence it is becoming a serious threat to the health of mankind. Commercially, a large number of drugs belonging to different classes, such as the Insulins, biguanides, sulfonylureas, meglitinides, and thiazolidinediones, DPP-4 inhibitors, SGLT2 INHIBITORS, and GLP1 AGONISTS are available to control and treat type 2 diabetic patients. However, none of these drugs are known to cure the diabetic phenotype completely. Furthermore, some of these agents can cause weight gain and have a limited role in the later stages of the disease. Newer formulations are reaching the market, which will help manage T2DM and improve patient outcomes.