Linezolid In Filariasis

Abstract

Wuchereria bancroft is the common filarial parasite that infects humans in this part of the world. The thread-like adult parasites reside in lymphatic channels or lymph nodes. Adult worms can cause lymphatic dilatation and thickening of the vessel walls. Lymphoedema and chronic stasis changes occur as complications. These are due to the direct effect of worms and the inflammatory effect of the host on the parasite. The inflammatory responses are believed to cause enhanced granulomatous reactions and fibrosis. Lymphatic obstruction results. Acute adenolymphangitis and chronic
lymphatic disease are the two varieties of the disease. Acute adenolymphangitis is characterized by high fever, lymphatic inflammation, and transient oedema. Linezolid is a synthetic Oxazolidinone antimicrobial drug, and it is indicated for gram-positive infections.