BK Polyoma Virus Infection in Renal Transplant Recipient

Abstract

he survival of renal transplant recipients has improved over years thanks to better critical care facilities, better evaluation methods for poorly functioning grafts, and better immunosuppressant agents being available. A 27 years old patient had hypertension for 8 years, but was on irregular treatment. He was diagnosed to have renal failure one year back. Initially patient was on renal replacement therapy and then he underwent allograft renal transplantation. Intraoperative and post-operative periods were uneventful with steady decline of S. Creatinine which attained a nadir of 1.3 mg% at the time of discharge. Patient was put on Tacrolimus, MMF and steroid. Patient was on regular follow-up with RFT monitoring. Serum creatinine value started rising after maintaining nadir for 3–4 months. On evaluation BK Virus infection was suspected. Urine was tested for BK viruria using PCR assay which was then confirmed with renal biopsy. The case is reported mainly to draw attention to the fact that BKVN is a cause of graft dysfunction.