Two cases of Hereditary Nephritis

Abstract

ALPORTS SYNDROME is a rare inherited progressive form of glomerular disease with deafness and ocular abnormalities. It is the second commonest genetic cause of renal failure. Thin basement membrane disease is thought to be underlying disease in 25% of patients with microscopic proteinuria. We hereby report two cases of Alport's syndrome in siblings.

Two brothers of 18 & 23 years were admitted with complaints of decreased urine output, swelling of both legs of one month duration