Midazolam Nasal Spray

Abstract

Midazolam is a short acting benzodiazepine available as Midazolam hydrochloride which is water soluble. It primarily acts as a CNS depressant enhancing the actions of inhibitory neurotransmitter GABA.  

Midazolam nasal spray is a new special formulation which is specifically indicated for intranasal administration of Midazolam during emergency situations like acute management of ongoing seizures in the pre hospital and intrahospital settings. Intranasal Midazolam may be prescribed for a child with epilepsy or febrile seizures who often has seizures lasting longer than five minutes or has a pattern of seizures that recur close together. It is also being used as a sedative for short outpatient surgical procedures.  

The clinical manifestations of Midazolam toxicity are mostly due to CNS depression and include somnolence, confusion, ataxia and coma.